A recent report from Lipedema Foundation urged for more investigation on the mutual relationship between growth and expansion of adipose tissue and function of the lymphatic system (Lontok et al., 2017). Our long-term goal is to improve lymphatic drainage from adipose tissue by locally stimulating lymphatic contractility in vivo and thus improving the clearance of lipid and inflammatory macromolecules from adipose depot. Our central hypothesis is that lymphatic targeting with nanomaterials capable of controlled release of small molecule contractility stimulators can directly enhance local lymphatic contractility and lymph transport in vivo, and this improvement in lymphatic function will restore SAT homeostasis in fat disorders.
Contact: Kim To